ANTI-CANCER EFFECT OF PLANTAGO DEPRESSA ETHANOLIC EXTRACT IN B16F10 SKIN CANCER CELLS

Authors

  • N V Ay School of Animal Sciences and Biotechnology, Mongolian University of Life Sciences, Ulaanbaatar, Mongolia College of Agriculture & Applied Biology, Can Tho University, Vietnam
  • Altantsetseg Kh School of Animal Sciences and Biotechnology, Mongolian University of Life Sciences, Ulaanbaatar, Mongolia
  • Enkhchimeg V School of Animal Sciences and Biotechnology, Mongolian University of Life Sciences, Ulaanbaatar, Mongolia
  • Baatartsogt O School of Animal Sciences and Biotechnology, Mongolian University of Life Sciences, Ulaanbaatar, Mongolia

DOI:

https://doi.org/10.5564/mjas.v21i02.902

Keywords:

Plantago depressa Willd, Plantago depressa ethanolic extract, anti-cancer effect, B16F10 skin cancer cells, in vitro,

Abstract

Plantago depressa Willd. is a distributed herb which traditionally used for treating wound, fever, cancer and inflammation in some temperate asian countries. This present study aimed to investigate the anti-cancer activity of ethanol extract of Plantago depressa Willd. plant on B16F10 skin cancer cells. Cells were treated with different concentration of the PDE (25, 50, 100, 200 μg/mL) with or without lipopolysaccharide (LPS) stimulation to evaluate its effect on cell viability. Furthermore, anti-cancer activity was evaluated by checking viability of B16F10 skin cancer cells in various concentration of the PDE extract (0.6, 1.2, 2.5 and 5 μg/mL), using CCK-8 assay. The results indicated that (i) the PDE treatment did not influence on cell viability of HaCaT skin normal cells dose-dependently; and (ii) PDE exhibits anti-cancer activity through inhibition of proliferation of B16F10 skin cancer cells.

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Published

2018-02-06

How to Cite

Ay, N. V., Kh, A., V, E., & O, B. (2018). ANTI-CANCER EFFECT OF PLANTAGO DEPRESSA ETHANOLIC EXTRACT IN B16F10 SKIN CANCER CELLS. Mongolian Journal of Agricultural Sciences, 21(02), 29–34. https://doi.org/10.5564/mjas.v21i02.902

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