Cytotoxicity screening of 114 Mongolian plant extracts on liver, colon, breast, and cervix cancer cell lines

Sarangerel Oidovsambuu; Tuul Tsagaantsooj; Davaapurev Bekh-Ochir; Nomin Myagmar; Indra Batjikh; Saruul Erdenebileg; Orgilkhatan Munkhuu; Odgerel Oidovsambuu; Batkhuu Javzan

doi:10.5564/mjc.v25i51.2934

Authors

Sarangerel Oidovsambuu Laboratory of Natural Product Chemistry, Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences, Ulaanbaatar 13330, Mongolia https://orcid.org/0000-0001-5062-7440
Tuul Tsagaantsooj School of Engineering and Technology, National University of Mongolia, Ulaanbaatar 14201, Mongolia https://orcid.org/0000-0003-2064-9205
Davaapurev Bekh-Ochir School of Engineering and Technology, National University of Mongolia, Ulaanbaatar 14201, Mongolia https://orcid.org/0000-0002-7623-2532
Nomin Myagmar School of Engineering and Technology, National University of Mongolia, Ulaanbaatar 14201, Mongolia https://orcid.org/0000-0002-3448-9137
Indra Batjikh School of Engineering and Technology, National University of Mongolia, Ulaanbaatar 14201, Mongolia https://orcid.org/0000-0002-7292-8487
Saruul Erdenebileg School of Engineering and Technology, National University of Mongolia, Ulaanbaatar 14201, Mongolia https://orcid.org/0000-0003-4474-7352
Orgilkhatan Munkhuu School of Engineering and Technology, National University of Mongolia, Ulaanbaatar 14201, Mongolia https://orcid.org/0009-0001-1594-654X
Odgerel Oidovsambuu School of Engineering and Technology, National University of Mongolia, Ulaanbaatar 14201, Mongolia https://orcid.org/0000-0001-6872-3385
Batkhuu Javzan School of Engineering and Technology, National University of Mongolia, Ulaanbaatar 14201, Mongolia https://orcid.org/0000-0002-8139-2311

DOI:

https://doi.org/10.5564/mjc.v25i51.2934

Keywords:

Medicinal plant, cytotoxicity, cancer cell line, ethanolic extract

Abstract

A total of 114 Mongolian plant species were subjected to cytotoxicity screening against liver (HepG2), colon (HCT116), breast (MCF7), and cervical (HeLa) cancer cell lines. Among them, ethanolic extracts of Androsace incana, Artemisia rutifolia, Saussurea amara, and Inula salsoloides exhibited remarkable cytotoxicity, with IC₅₀ values below 1.5 μg/mL against at least 2 tested cell lines when treated for 48 hours. Erysimum flavum, Juniperus sibirica, and Stellaria dichotoma demonstrated selective cytotoxicity against specific cancer cell lines. Extracts from 23 plant species, such as Artemisia xerophytica, Ajania trifida, Melandrium brachypetalum, Brachanthemum mongolicum, and Rhinanthus songaricus, showed moderate toxicity. Further research on the phytochemicals and biological activities of these species is crucial for a deeper understanding and potential applications. These screening results of the cytotoxic effects of numerous Mongolian plants could establish a foundational dataset for subsequent comprehensive studies on the screened plants.

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