Mongolian Journal of Chemistry <p>published by the Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences.</p> <p><strong>Abstracting and indexing in</strong> <a title="DOAJ" href="" target="_blank" rel="noopener">DOAJ</a>, <a title="EBSCO" href="" target="_blank" rel="noopener">EBSCO Discovery Service</a>, <a title="Google Scholar" href="" target="_blank" rel="noopener">Google Scholar</a>, <a title="MJC" href="" target="_blank" rel="noopener">Dimensions</a>, <strong>CAS databases, <a title="CNKI" href="" target="_blank" rel="noopener">CNKI</a>, </strong>and <a title="MJC - Scopus" href="" target="_blank" rel="noopener"><strong>Scopus</strong></a></p> en-US <p>Copyright on any research article in the <strong>Mongolian Journal of Chemistry</strong> is retained by the author(s).</p> <p>The authors grant the <strong>Mongolian Journal of Chemistry</strong> a license to publish the article and identify itself as the original publisher.</p> <p><a href="" rel="license"><img style="border-width: 0;" src="" alt="Creative Commons Licence"></a><br>Articles in the <strong>Mongolian Journal of Chemistry</strong> are Open Access articles published&nbsp;under a <a href="" rel="license">Creative Commons Attribution 4.0 International License</a> CC BY.</p> <p>This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.</p> (Dr. Munkhtsetseg Tsednee) (Gantulga Lkhagva) Thu, 01 Feb 2024 00:00:00 +0000 OJS 60 Antibacterial and photocatalytic effects of newly synthesized zinc oxide nanoparticles derived from Mongolian honey <p>Development of bio-compatible, bio-safe and environmentally friendly nanoparticles is a matter of urgency for research in the field of nanotechnology. In this study, we aimed to prepare zinc oxide nanoparticles from Mongolian honey as raw material and to determine its biological activities. Honey-based zinc oxide nanoparticles were obtained by green synthesis method, and their characteristics and biological activities were evaluated. Developed zinc oxide nanoparticles from Khentii honey and Selenge honey were at a size of 16.02 nm and 95.23 nm, respectively. A characteristic band of Khentii honey-based zinc oxide nanoparticles was observed at 466 cm<sup>–1</sup> and a band of Selenge honey-based zinc oxide nanoparticles was also observed at 434 cm<sup>–1</sup>. Antibacterial and photocatalytic effects were detected for the developed nanoparticles. The study suggested that newly synthesized honey-based zinc oxide nanoparticles might be an effective tool against bacterial infection.</p> Anujin Lkhagvadorj, Tserendolgor Batsukh, Altansukh Tsend-Ayush Copyright (c) 2024 Anujin Lkhagvadorj, Tserendolgor Batsukh, Altansukh Tsend-Ayush Mon, 20 May 2024 00:00:00 +0000 Cytotoxicity screening of 114 Mongolian plant extracts on liver, colon, breast, and cervix cancer cell lines <p>A total of 114 Mongolian plant species were subjected to cytotoxicity screening against liver (HepG2), colon (HCT116), breast (MCF7), and cervical (HeLa) cancer cell lines. Among them, ethanolic extracts of <em>Androsace incana</em>, <em>Artemisia rutifolia</em>, <em>Saussurea amara</em>, and <em>Inula salsoloides</em> exhibited remarkable cytotoxicity, with IC<sub>50</sub> values below 1.5 μg/mL against at least 2 tested cell lines when treated for 48 hours. <em>Erysimum flavum</em>, <em>Juniperus sibirica</em>, and <em>Stellaria dichotoma</em> demonstrated selective cytotoxicity against specific cancer cell lines. Extracts from 23 plant species, such as <em>Artemisia xerophytica</em>, <em>Ajania trifida</em>, <em>Melandrium brachypetalum</em>, <em>Brachanthemum mongolicum</em>, and <em>Rhinanthus songaricus</em>, showed moderate toxicity. Further research on the phytochemicals and biological activities of these species is crucial for a deeper understanding and potential applications. These screening results of the cytotoxic effects of numerous Mongolian plants could establish a foundational dataset for subsequent comprehensive studies on the screened plants.</p> Sarangerel Oidovsambuu, Tuul Tsagaantsooj, Davaapurev Bekh-Ochir, Nomin Myagmar, Indra Batjikh, Saruul Erdenebileg, Orgilkhatan Munkhuu, Odgerel Oidovsambuu, Batkhuu Javzan Copyright (c) 2024 Sarangerel Oidovsambuu, Tuul Tsagaantsooj, Davaapurev Bekh-Ochir, Nomin Myagmar, Indra Batjikh, Saruul Erdenebileg, Orgilkhatan Munkhuu, Odgerel Oidovsambuu, Batkhuu Javzan Wed, 27 Mar 2024 00:00:00 +0000 Synthesis and biological evaluation of some novel benzoxazin-4-one and quinazolin-4-one derivatives based on anti-inflammatory commercial drugs <p>Benzoxazine and quinazoline are nitrogen-containing heterocyclic scaffolds found in various biologically active compounds. Due to their diverse biological actions, these heterocyclic rings serve as crucial frameworks for designing medicinal compounds. This study aimed to synthesize and assess <em>in vivo</em> anti-inflammatory, analgesic, and low ulcerogenic potential of a few novel benz[<em>d</em>][1,3]-oxazin-4-one and quinazolinone derivatives. Benzoxazinones (<strong>3a-e</strong>) were synthesized by cyclizing the carboxylic group (-COOH) of five nonsteroidal anti-inflammatory drugs <em>viz.,</em> aceclofenac, ibuprofen, diclofenac, mefenamic acid and ketoprofen (<strong>2a-e</strong>) with anthranilic acid (<strong>1</strong>) using dry phosphorus oxychloride (POCl<sub>3</sub>) in pyridine. The corresponding quinazolinone derivatives (<strong>5a-e</strong>) were obtained by reacting <strong>3a-e</strong> with isonicotinic acid hydrazide (<strong>4</strong>). Both sets of compounds were evaluated for their anti-inflammatory, analgesic effects, and ulcerogenicity in animal models. Structural characterization was performed using spectral analysis. Among the benzoxazinone derivatives, compound 2-(2-((2,6-dichlorophenyl) amino) benzyl)-4<em>H</em>-benzo[<em>d</em>][1,3]oxazin-4-one<strong> (3d)</strong> exhibited significant anti-inflammatory activity (62.61% inhibition of rat paw edema) and analgesic activity (62.36% protection in acetic acid-induced writhings) with tolerable gastrointestinal toxicity (2.67 ulcerogenicity index) compared to quinazolinone derivatives. The results of anti-inflammatory and analgesic activities of both the series are comparable with the respective, positive control. Compound <strong>3d</strong>, a benzoxazinone-diclofenac hybrid, emerged as a lead molecule with potent anti-inflammatory, analgesic activities and moderate gastric toxicity showcasing the promising potential for further development.</p> Shah Alam Khan, Priyanka Ahuja, Asif Husain Copyright (c) 2024 Shah Alam Khan, Priyanka Ahuja, Asif Husain Mon, 22 Apr 2024 00:00:00 +0000 Engineering polyamide materials: s-triazine framework with specialized bulky side chains for advanced applications <p>The focus of this study is on the synthesis of organic fluorescent and thermally stable polyamides using an s-triazine frame. Coumarin and n-phenyl anthranilic acid have been utilized as bulky pendent groups in the synthesis of the monomer, resulting in polyamides with two groups that enhance stability and fluorescence. The synthesized polyamides have been characterized using a variety of techniques. The thermal stability of the polyamides has been studied using thermogravimetric analysis. These polyamides offer appealing features such as fluorescence and enhanced thermal stability, making them significant for a wide range of applications, including biosensors, clean energy technologies, and explosive sensing.</p> Deep Bhalani, Sabir Khan Pathan, Jignasa V.Modh Copyright (c) 2024 Deep Bhalani, Sabir Khan Pathan, Jignasa V.Modh Mon, 13 May 2024 00:00:00 +0000 Study of Oxadiazole derivatives as precursor for multi-functional inhibitor to SARS-CoV-2: A detailed virtual screening analysis <p>SARS-CoV-2, the virus responsible for the COVID-19 pandemic, is highly contagious and has caused widespread loss of life. In the quest to find effective antiviral agents, attention has turned to oxadiazole derivatives, which are known for their potential antiviral properties in such as CoViTris2020, ChloViD2020, etc. To evaluate their effectiveness, molecular docking and molecular dynamics simulations are conducted for various oxadiazole derivative in interactions with critical proteins involved in the viral infection process. These proteins encompass transmembrane-serine-2 (TMPRSS2), 3-chymotrypsin-like-protease (3CLpro), angiotensin-converting-enzyme-2 (ACE2), and papain-like-protease (PLpro). The study shows that the oxadiazole derivatives exhibited their most stable complexes when interacting with TMPRSS2 in comparison to 3CLpro, ACE2, and PLpro. In particular, Oxa8 displayed a binding energy of -6.52 kcal/mol with TMPRSS2. In contrast, the binding energies with ACE2, 3CLpro, and PLpro were -5.74, -4.56, and -5.56 kcal/mol, respectively. RMSD analysis during MD simulations demonstrated that the complex structure remained consistently stable. During the initial 2 ns, the RMSD value for the ligand concerning its interaction with the protein backbone hovered around 2 Å, indicating a sustained level of structural stability. In conclusion, this study suggests that oxadiazole derivative Oxa8 holds promise as a potential inhibitor of SARS-CoV-2, particularly due to its strong binding affinity with TMPRSS2 and its enduring structural stability observed in molecular dynamics simulations.</p> Vikash Kumar, Sumit Kumar Copyright (c) 2024 Sumit Kumar, Vikash Thu, 01 Feb 2024 00:00:00 +0000