Immunological characterization of Neospora caninum Cyclophilin

Authors

  • Myagmarsuren Punsantsogvoo Laboratory of Molecular Genetics, Institute of Veterinary Medicine
  • Hany Ibrahim National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
  • Narantsatsral Sandagdorj Laboratory of Molecular Genetics, Institute of Veterinary Medicine
  • Battur Banzragch Laboratory of Molecular Genetics, Institute of Veterinary Medicine
  • Battsetseg Badgar Laboratory of Molecular Genetics, Institute of Veterinary Medicine
  • Xuenan Xuan National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
  • Yoshifumi Nishikawa National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine

DOI:

https://doi.org/10.5564/mjas.v11i2.209

Keywords:

Neosporosis, Neospora caninum, NcCyp18

Abstract

Neosporosis is caused by an intracellular protozoan,Neospora caninum, which is an important pathogen of dogs and cattle. In this study, we analyzed Neospora caninum cyclophilin 18 protein (NcCyp18), which regulates proliferation and migration of murine macrophages and lymphocytes. From our study, NcCyp18 showed the activity of macrophage proliferation in a CCR5-independent manner and activity of spleen cell proliferation in a CCR5-dependent manner. NcCyp18 showed the activity of macrophage migration in a CCR5-independent manner and activity of spleen cell migration in a CCR5-dependent manner. Moreover, recombinant NcCyp18 induced the production of the nitric oxide and IL-12 p40. The data suggest that NcCyp18 recruits host cells and enhances the growth of host cells at the site of infection for maintenance of interaction between the parasite and host.

DOI: http://dx.doi.org/10.5564/mjas.v11i2.209

Mongolian Journal of Agricultural Sciences Vol.11(2) 2013 pp.17-23

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Published

2014-11-24

How to Cite

Punsantsogvoo, M., Ibrahim, H., Sandagdorj, N., Banzragch, B., Badgar, B., Xuan, X., & Nishikawa, Y. (2014). Immunological characterization of Neospora caninum Cyclophilin. Mongolian Journal of Agricultural Sciences, 11(2), 17–23. https://doi.org/10.5564/mjas.v11i2.209

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