Trichostatin A, a potential drug for treatment of animal Babesia infections

Authors

  • T Nyamjargal National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
  • N Oshima National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
  • X Xuan National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
  • I Igarashi National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine
  • T Munkhjargal Institute of Veterinary Medicine
  • H Suzuki National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine

DOI:

https://doi.org/10.5564/mjas.v11i2.210

Keywords:

Chemotherapy, in vitro, in vivo, parasites

Abstract

In the present study, we evaluated the inhibitory effect of trichostatin A on the asexual growth of bovine, equine, and canine Babesia parasites in vitro as well as on the in vivo growth of Babesia microti (B.microti) in mice. The growth of Babesia bovis (B.bovis), Babesia bigemina (B.bigemina), Babesia caballi (B.caballi), Theileria equi (T.equi), and Babesia gibsoni (B.gibsoni) species was significantly inhibited (P < 0.05) by very low concentrations of trichostatin A (IC50 values = 2.6, 2.4, 2.3, 2.4, and 2.3 nM, respectively). Furthermore, in B.microti-infected mice, trichostatin A caused significant higher (P < 0.05) inhibition of the growth of B.microti at the dose of 2 mg/kg body weight than that in the control group. These results indicated the trichostatin A might be a chemotherapeutic agent for treatment of babesiosis.

DOI: http://dx.doi.org/10.5564/mjas.v11i2.210

Mongolian Journal of Agricultural Sciences Vol.11(2) 2013 pp.24-26

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Published

2014-11-24

How to Cite

Nyamjargal, T., Oshima, N., Xuan, X., Igarashi, I., Munkhjargal, T., & Suzuki, H. (2014). Trichostatin A, a potential drug for treatment of animal Babesia infections. Mongolian Journal of Agricultural Sciences, 11(2), 24–26. https://doi.org/10.5564/mjas.v11i2.210

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