Antioxidant and Anticonvulsant Effects of Medicinal Herbs

Authors

  • J Aldarmaa Traditional Medicine, Science Technology Production Corporation, Ulaanbaatar
  • J Liu Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai
  • J Long Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,Shanghai
  • O Nyamdalai Hospital “Bolor melmiins”
  • J Ariunaa Institute of biochehnology, Ulaanbaatar

DOI:

https://doi.org/10.5564/pmas.v0i4.37

Keywords:

Maximal electroshock, Pentylenetetrazol, hydroxyl radical, lipid radical

Abstract

This study examines the anticonvulsant profile of some medicinal plants (astragalus mongolicus, corydalis sibirica, scutellaria baicalensis and Chelidonium majus) and antioxidant effects of Astragalus mongolicus and Chelidonium majus. Astragalus mongolicus and Chelidonium majus extracts possessed a significant dose-dependent scavenging effect on hydroxyl and lipid radicals by an in vitro ESR technique. Astragalus mongolicus (150 and 300mg/kg) and Scutellaria baicalensis (150 and 300mg/kg) extracts had anticonvulsant activities in the Pentylenetetrazol (PTZ). Maximal Scutellaria baicalensis in a dose of 150 and 300mg/kg significantly shortened the latency period seizures in the maximal electroshock (MES). Corydalis sibirica (150mg/kg) and Chelidonium majus (150 and 300mg/kg) extracts didn't influence on latency period in the PTZ and MES models. All extracts improved losing memory by passive avoidance task (longterm memory) and significantly didn't influence on drinking punishment in the Vogel's test.

DOI: http://dx.doi.org/10.5564/pmas.v0i4.37

Proceedings of the Mongolian Academy of Sciences 2007 No 4 pp.3-16

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Published

2011-03-18

How to Cite

Aldarmaa, J., Liu, J., Long, J., Nyamdalai, O., & Ariunaa, J. (2011). Antioxidant and Anticonvulsant Effects of Medicinal Herbs. Proceedings of the Mongolian Academy of Sciences, 47(4), 3–16. https://doi.org/10.5564/pmas.v0i4.37

Issue

Vol. 47 No 04(186) 2007

Section

Articles

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