A Risk Assessment of Gastric Cancer and Precancerous Condition Using Serum Pepsinogen and H. Pylori Antibody Test

Authors

  • Ganchimeg Dondov Department of Gastroenterology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Bayarmaa Nyamaa Department of Gastroenterology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Tegshjargal Badamjav Department of Internal Medicine, Institute of Medical Sciences, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Batbold Batsaikhan Department of Internal Medicine, Institute of Medical Sciences, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Erkhembulgan Purevdorj Department of Internal Medicine, Institute of Medical Sciences, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Dashmaa Amarbayasgalan Department of Radiology, National Cancer Center, Ulaanbaatar, Mongolia
  • Chinzorig Munkhjargal Department of General Surgery, National Cancer Center, Ulaanbaatar, Mongolia
  • Erkhembayar Enkhbat Department of General Surgery, National Cancer Center, Ulaanbaatar, Mongolia
  • Sodnomtsogt Lkhagvasuren Department of Internal Medicine, Institute of Medical Sciences, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
  • Tulgaa Lonjid Department of Internal Medicine, Institute of Medical Sciences, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia https://orcid.org/0000-0002-2565-0347

DOI:

https://doi.org/10.24079/cajms.2023.03.003

Keywords:

Biological marker, Cancer screening, Atrophic gastritis, Screening test, Stomach neoplasm

Abstract

Objectives: We aimed to determine serum PGs (serum pepsinogens) and H. Pylori IgG in atrophic gastritis and gastric cancer patients and evaluate the gastric cancer risk.
Method: We enrolled 40 gastric cancer patients, 40 chronic atrophic gastritis patients and 40 healthy control subjects. Serum PGI, PGII, and H. pylori IgG levels were measured by ELISA. The PGI to PGII ratio was calculated.
Results: The mean age of the subjects was 60±10.9 years, We found that 52.6% (n=60) were male. H. Pylori IgG was positive in 67 subjects. The serum PGI and PGR levels were significantly decreased in gastric cancer and atrophic gastritis groups compared to the healthy control. According to classification ABC (D), group D had higher proportion of atrophic gastritis cases, group C had higher proportion of gastric cancer cases than others. Additionally, we evaluated all subjects by giving one point to each of the age ≤40, positive family history of gastric cancer, positive previous gastric disease history, PGI ≤75.07 ng/ml, PGR ≤6.25, or two point to each of PGI ≤35.25 ng/ml, and PGR ≤5.27, with score ranging between 0-7. As score increased, the risk of atrophic gastritis or gastric cancer increased.
Conclusion: A combination of methods involving PGs and other risk factors may predict the probability of gastric cancer and could identify individuals who may need upper endoscopy.

Abstract
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Author Biographies

Ganchimeg Dondov, Department of Gastroenterology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

Department of Internal Medicine, Institute of Medical Sciences, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

Tegshjargal Badamjav, Department of Internal Medicine, Institute of Medical Sciences, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

Department of Biological Sciences, College of Life Sciences, Inner Mongolia University, Huhhot, China

Sodnomtsogt Lkhagvasuren, Department of Internal Medicine, Institute of Medical Sciences, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

Department of Science and Technology, Mongolian National University of Medical Sciences, Ulaanbaatar,
Mongolia

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Published

2023-03-30

How to Cite

Dondov, G., Nyamaa, B., Badamjav, T., Batsaikhan, B., Purevdorj, E., Amarbayasgalan, D., Munkhjargal, C., Enkhbat, E., Lkhagvasuren, S., & Lonjid, T. (2023). A Risk Assessment of Gastric Cancer and Precancerous Condition Using Serum Pepsinogen and H. Pylori Antibody Test. Central Asian Journal of Medical Sciences, 9(1), 15–21. https://doi.org/10.24079/cajms.2023.03.003

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