Separation and purification of curcumin preparation of morphology controlled micro particles

Authors

  • Ts Tsedendorj Institute of Chemistry and Chemical Technology, MAS
  • Hong Hai-long Chemical engineering college, Inner Mongolia University of Technology
  • Han Li-min Chemical engineering college, Inner Mongolia University of Technology
  • N Lkhagvajav Plant Protection Research Institute, Ulaanbaatar
  • B Darkhijav Institute of Chemistry and Chemical Technology, MAS

DOI:

https://doi.org/10.5564/mjc.v15i0.314

Keywords:

Curcumin, Supercritical fluid, Micro particle, Morphology

Abstract

Curcumin was extracted from turmeric plants which is the most commonly used natural pigments, and possess a variety of pharmacological functions except for using pigment. The morphology and particle size of curcumin are main factors affecting the application. Therefore, the morphology and particle size distribution of curcumin were effectively controlled by advanced technology, which is significant for expanding the application and added value of curcumin. The curcumin crystal was obtained from curcumin pigments by using column chromatography and recrystallization techniques. The composition and structure of curcumin were characterized by elementary analysis, UV-Vis, IR and NMR. Micronization of curcumin was carried out the Solution Enhanced Dispersion by Supercritical Fluids (SEDS) technology. In the process, supercritical carbon dioxide was used as anti-solvent and acetone/dichloromethane (1:4, v:v) was used as solvent. The curcumin crystals with PSs of about 378 μm were successfully micronized by the SEDS process to micro particles with PSs of about 2.6-10 μm. The acicular, leaves, dendritic and tubular micro particles were obtained through controlling parameters such as pressure, temperature, solution concentration and solution flow rate.

DOI: http://doi.dx.org/10.5564/mjc.v15i0.314

Mongolian Journal of Chemistry  15 (41), 2014, p11-14

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Published

2014-12-12

How to Cite

Tsedendorj, T., Hai-long, H., Li-min, H., Lkhagvajav, N., & Darkhijav, B. (2014). Separation and purification of curcumin preparation of morphology controlled micro particles. Mongolian Journal of Chemistry, 15, 11–14. https://doi.org/10.5564/mjc.v15i0.314

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Articles