Coumarins from Peucedanum hystrix growing in Mongolia

It is proved to be that of genus Peucedanum hystrix serve as a source of biologically valuable natural coumarins. Nine angular furocoumarins belonging to class of 2'-substituted and 2',3'-disubstituted 2',3'-dihydrofurocoumarins have been isolated and structurally isolated. For peucenidin data of X-ray analysis is obtained.


Introduction
lants of Umbelliferae family are known to be a good source of naturally occurring coumarins for producing of potential medicinal preparations [1].Coumarins are considered as phytoalexins since plants produce them as defence substances when wounded or attacked by other organisms.Coumarins can be suggested to be beneficial for the plants themselves as natural biocontrolling antipathogenic compounds and for humans as remedy for hyperproliferative skin deseases and as reference compounds in various bioactive tests.Furthermore, coumarin containing plants are valuable as dietary supplements on the basis of their mild antimicrobial and antiinflammatory effects.Coumarins are also active in plant metabolism, taking part in growth regulation.

Results and Discussion
We have investigated extractive compounds from Peucedanum hystrix Bge.collected from the place named Batkhaan uul, Uvurkhangai province.Concentrated ethanolic extract of the aerial parts and roots successively fractionated with hexane, chloroform, diethyl ether and ethyl acetate.The yield of extractive compounds and total content of coumarins in fractions after evaporation of hexane, chloroform and diethyl ether have shown at table 1.Total content of coumarins in the aerial parts and roots were 3.9 and 4.6%.The highest content of coumarins indicated in hexane and chloroform fractions.Extractive compounds separated by column chromatography on silica gel.
Thus, we have obtained new data about metabolites composition of the plant Peucedanum hystrix Bge.It is proved to be that this plant might serve as source of 2'substituted and 2',3'-disubstituted 2',3'dihydrofurocoumarins. Deserve attention isolation from Peucedanum hystrix Bge.highly distributed in plants chromone 4 [11] as well as vanilic 16 and trans-ferulic 17 acid.

Conclusions 1. It is proved to be that plants of genus
Peucedanum hystrix might serve as source of biologically valuable natural coumarins.

Таble 2 .
Parameters of intramolecular and intermolecular hydrogen bonds in the crystal of the compound 8.